GRM8 and LY6G6D/F were differentially expressed by this method, but had high percentages of expression in normal colon, i.e. were less able to distinguish CRC from normal tissues, these markers scored 26% and 36% ≥4 in normal colon tissue respectively, compared to 63% and 88% ≥4 for adenomas. The gene discussed is GRM8; the disease is adenoma.