Notably, GPR56, GRM8, LY6G6D/F and SLCO1B1/3/7 had lower mean expression values in other GI tissues relative to CRC, while TLR4 had elevated expression in tissues of the mouth and CLDN1 had elevated expression in tissues of the mouth and esophagus (Figure 1). This evidence concerns the gene TLR4 and colorectal carcinoma.