CASP8 and non-small cell lung carcinoma: Although it remains to be determined how gemcitabine induces caspase-8 activation, it has also been reported that gemcitabine induces apoptosis in non-small cell lung cancer (NSCLC) cells by increasing expression of functionally active Fas (CD95, APO-1) and up-regulating Fas ligand (FasL) [26, 27].