EGFR and bone metastasis: In the multivariable analysis, prolonged PFS was independently associated with an ECOG PS of ≤2 (p = 0.006), common EGFR mutations (p < 0.001), no bone metastasis (p < 0.001), no liver metastasis (p = 0.005), and no pleural metastasis (p = 0.004) (Table 2).