HMOX1 and triple-A syndrome: Induction of HO-1 in HO-1 Het mice by IP administration of heme resulted in an increase in HO activity in livers (Fig 1A, left panel) and aortae (Fig 1B, left panel) and reduced the progression of AAA in response to PPE to a level similar to that for WT mice at 7, 14, 21, and 28 days post-PPE infusion (Fig 2).