To determine the effects of HMGA2 inhibition in CRC cells, cell proliferation and cell migration assays were performed; siHMGA2 knockdown significantly reduced mRNA expression level of HMGA2 (Fig. S4A) and the proliferation rate of siHMGA2-transfected HCT116 cells (Fig. 2A). This evidence concerns the gene HMGA2 and colorectal carcinoma.