PTK2 and colorectal carcinoma: Extracellular Signal-Regulated Kinase (ERK) and FAK have been demonstrated to be regulated by Hsp90 and were involved in HMGA2-regulated CRC cell growth and mobility (Chen et al., 2010; Li et al., 2013; Li et al., 2014; Ory et al., 2015; Zhang et al., 2015a).