AWAT1 and fatty liver disease: For example, overexpression of diacylglycerol acyltransferase 2 (DGAT2) which catalyzes the final step in triacylglycerol (TG) biosynthesis in the liver increases hepatic steatosis, manifested as increased amounts of hepatic TG, diacylglycerol, ceramides, and unsaturated long-chain fatty acyl-CoAs.