ERN1 and diabetic kidney disease: Lakshmanan et al. [19] have also reported that the AT1R-specific blocker, olmesartan, blunted the upregulated GRP78 and ER-associated apoptosis proteins, such as TRAF2, IRE-1α, CHOP, p-JNK, and procaspase-12, in STZ-induced diabetic mice, which suggested that Ang II inhibition could be a potential therapy in treating ERS-induced renal apoptosis via the modulation of AT-1R/CHOP-JNK-Caspase-12 pathway in STZ-induced diabetic nephropathy.