In human cancer cells, inhibition of lipid raft-associated PI3-kinase/PKB (Akt) signaling by TSWU-CD4, a synthetic bichalcone analog, induced ERS- and oligomeric Bax/Bak-mediated apoptosis, which were substantially reversed by overexpression of the wt PI3-kinase p85α subunit. Here, BAK1 is linked to cancer.