CXCL8 and alkaline phosphatase measurement: To our knowledge, nucleosomes, as demonstrated in the present study, and the adenosine-generating ecto-5′-nucleotidase/CD73 [11] and the cytokines interleukin 8, hepatocyte growth factor, and granulocyte-colony stimulating factor [12], are so far the only markers that may aid to identify the patients who present without signs of OD but are bound to develop it during the course of AP.