In contrast, muscle fibers from COPD patients exhibited no differences in TFAM expression between COX-normal and COX-deficient fibers of neither MHC type (type 1 COX-deficient 21,706, COX-normal 20,688 ± 1782 A.U.; type 2 COX-deficient 16,868 ± 1737, COX-normal 16,731 ± 652.4; Fig. 6c) corresponding to a failed regulatory response across both slow and fast muscle fibers. This evidence concerns the gene TFAM and chronic obstructive pulmonary disease.