Although still correlative, our discovery that loss of SLC27a6 ACS function is associated with leukodystrophy is highly provocative based on ACS loss-of-function studies in the fly reported here and elsewhere (Dourlen et al., 2012), and of high potential significance given clinicians' frequent inability to recognize the heritable basis of leukodystrophy, a debilitating and oftentimes lethal condition of childhood (Gordon et al., 2014). Here, SLC27A6 is linked to leukodystrophy.