On their own, the mutant KRAS transgene and the axin mutation cause intestinal epithelial hyperplasia and increase epithelial cell proliferation, respectively, in zebrafish larvae, but do not cause cell invasion or neoplasia (Cheesman et al., 2011; Langenau et al., 2007; Seiler et al., 2012). The gene discussed is AXIN1; the disease is neoplasm.