MYH11 and vascular disorder: MYH11 coding variants and MYH11 copy-number variants cause heritable and sporadic vascular disease, including familial TAAD (with or without patent ductus arteriosus), sporadic TAAD, and other sporadic human vascular disorders (Bee et al., 2012; Kuang et al., 2011; Pannu et al., 2007; Zhu et al., 2006).