MYH11 variants have also been detected in individuals with hereditary non-polyposis colorectal cancer (HNPCC), those with a form of microsatellite instability (MSI) colorectal cancer, and in cases of sporadic cancer with stable microsatellites (MSS cancer) (Alhopuro et al., 2008; Vickaryous et al., 2008). The gene discussed is MYH11; the disease is colorectal cancer.