To identify the functional effect of ANAPC1 rs3814026C>T, ETS2 rs461155A>G, SORBS1 rs7081076C>A and POLR2A rs2071504C>T, we evaluated the relationship between the genotypes of those SNPs and mRNA expression of each gene in tumor and paired non-malignant lung tissues. This evidence concerns the gene POLR2A and neoplasm.