MT1-MMP localizes to the plasma membrane to induce MMP-2 activation [20], and that intracellular trafficking of subcellular organelles may be regulated by mDia1 [23, 24]; therefore, we hypothesized that mDia1 could be involved in the localization of MT1-MMP to the plasma membrane to induce cancer cell invasion. This evidence concerns the gene MMP14 and cancer.