However, as we only collected 59 ESCC samples in our study, we did not observe significant correlation between DEPTOR expression and tumor differentiation, this may be own to the restrict in number of some subpopulations (like well differentiation group only include 4 samples), and the correlation analysis may be need to be reexamined in a large patient population. This evidence concerns the gene DEPTOR and esophageal squamous cell carcinoma.