MTOR and cancer: As an mTOR binding protein that normally functions to inhibit the mTORC1 and mTORC2 pathways, DEPTOR is considered as a tumor suppressor protein with the reason that mTOR activity is mostly hyperactivated in many human tumors [4, 23, 24], Indeed, down-regulation of DEPTOR has been found in many types of human cancers [7–10, 17].