A previous report suggested that the abnormal activation of T cells, especially the Th17 cell subset, contributes to the pathogenesis of psoriasis, and Th17 cell-related cytokines, including IL-17, IL22, and IL-6, are responsible for the altered proliferation and differentiation of keratinocytes and the induction of Stat3 signaling15. The gene discussed is STAT3; the disease is psoriasis.