It has been showed that inflammatory cytokines could induce the expression of five subunits of constitutive proteasome (iβ1 [LMP2], iβ2 [LMP10], iβ5 [LMP7], PA28α, and PA28β), which assemble on the proteasome core to create the immunoproteasome [31, 32], and this immunoproteasome might have an important role in mediating OSCC tumor generation. The gene discussed is MAPK8IP2; the disease is neoplasm.