HNF4A and neoplasm: An increase in β-catenin protein stability determines the levels of cytoplasmic β-catenin accumulation and nuclear β-catenin binding with the T-cell factor/lymphoid enhancer factor (TCF/LEF) or other transcription factors, thereby upregulating several downstream genes, such as cyclin D1 and c-Myc, to promote tumor progression8, 9, 10.