For the case of breast cancer subtypes, we have found seven exclusive subtype-related pathways, including glycine serine and threonine metabolism pathway for Luminal B, glycerolipid metabolism, fatty acid metabolism, complement and coagulation cascades and bladder cancer for HER2 and small cell lung cancer and metabolism of xenobiotics by cytochrome p450 for Triple Negative. The gene discussed is ERBB2; the disease is urinary bladder cancer.