However, it is important to note that among the identified proteins already implicated in dementia pathology, many were enriched in the soluble fraction rather than the aggregated pellet (including GFAP, GAP43, MBP, SNAP25, BASP1, IGKC, TUBB4B, TBB8L, TUBB4A [42–44]), suggesting that full elucidation of disease pathogenesis will require a better understanding of changes in brain protein structure and function outside of the plaque. This evidence concerns the gene GAP43 and dementia.