ITGAL and psoriasis: Efalizumab is a recombinant humanised monoclonal antibody which binds to the CD11a subunit of LFA-1 and acts as an immunosuppressant by inhibiting lymphocyte activation and cell migration out of blood vessels into tissues, which was not superior to placebo in treating PsA [64], despite being proven effective in treating psoriasis [64, 65].