ME1 and hydrops fetalis: Different factors in coenzyme metabolic processes such as those related to the synthesis of cytosolic acetyl-CoA (ACLY) and lipid anabolic process (ME1, HMGCR) were also all down-regulated by the HF diet, with the noticeable exception of glutathione S-transferase kappa 1 (GSTK1) which functions in cellular detoxification.