Conversely, IGF1R coding for the insulin-growth factor 1 receptor binding IGF-I, a well-known regulator of cell development, and which was first listed in the significantly-enriched phosphorus metabolic process, was also included in the less enriched clusters corresponding to the response to hormone stimulus and the regulation of cell death; this gene was one of the top genes being up-regulated by HF diet. Here, IGF1 is linked to hydrops fetalis.