CDKN2A and mesothelioma: Deleterious alterations of NF2 and CDKN2A (p16INK4A/p14ARF) have been implicated in mesothelioma development10, 16, 27 and are of great importance in determining appropriate therapeutic strategies.16 We examined the status of p16INK4A/p14ARF genetic loci in both primary and commercial mesothelioma cell lines (Figure 4a and b).