Depression score was significantly associated with VFA and fasting insulin in men; multivariable-adjusted ORs (95% CI) of high VFA for the lowest through highest quartile of depression score were 1 (reference), 1.18 (0.97–1.42), 1.25 (1.02–1.54), 1.23 (1.01–1.51), respectively (P for trend = 0.03), and the corresponding figures for high fasting insulin were 1 (reference), 0.98 (0.80–1.19), 1.12 (0.91–1.38), and 1.29 (1.06–1.57), respectively (P for trend <0.01). This evidence concerns the gene INS and depressive disorder.