PSCA rs2294008 was associated with increased overall cancer risk (TT vs.CC: OR = 1.28, p = 0.002; CT vs.CC: OR = 1.21, p ≤ 0.0001; CT + TT vs.CC: OR = 1.24, p ≤ 0.0001; TT vs.CC + CT; OR = 1.17, p ≤ 0.005, T vs.C allele: OR = 1.16, p ≤ 0.0001); however, in stratified analysis this association was limited only to gastric and bladder cancer and the strength was more prominent in Asians. Here, PSCA is linked to urinary bladder cancer.