EGFR and neoplasm: Provided that miRNAs induce transcriptional repression through complementary pairing of the 3′-untranslated region (UTR) with the transcripts of interest, it is plausible to postulate that the introduction of miRNA mimetics may reduce the expression, activity and signal transduction of EGFR such that the cytotoxicity of gefitinib can be restored in tumours exhibiting impaired drug response [3].