If signals in or near C12orf51 originated from a region of the ALDH2 gene, wild-type C12orf51 should have reduced the risk of T2D in never-drinkers, but minor allele homozygote of C12orf51 significantly reduced the risk of T2D among never-drinkers in the present study. The gene discussed is ALDH2; the disease is type 2 diabetes mellitus.