We restrict our analysis to the 3 major conditions identified in an earlier work.6 Low denervation, which skews D2R signaling but without random aberrant signaling (<70% denervation, Fig. 4A), excess coherent denervation, where random postsynaptic activation may lead to the first motor manifestations of PD (Fig. 4B), and the presence of voids with complete denervation (Fig. 4C). The gene discussed is DRD2; the disease is Parkinson disease.