PLG and infection: A diverse array of ECM-binding proteins has been identified suggesting a redundancy of adhesion molecules that are probably part of invasion strategies of Leptospira. Indeed, many putative adhesins are multifunctional as they bind plasminogen and generate plasmin [185, 196, 197], increasing proteolytic processes associated with infection, or they could participate in immune evasion strategies by interacting with complement regulators (see below).