ANGPT2 and Hyperglycemia: Local vascular leakage occurs early in the experimental diabetic mice even before the pericyte loss.5 In addition, Ang2 is upregulated by hyperglycemia in endothelial cells and diabetic retina.17, 18, 19 Moreover, Ang2 binds to integrin and regulates angiogenesis.20 In view of neurovascular unit, we postulated that Ang2 could affect astrocyte via integrin signaling before the pericyte loss in diabetic retina.