Recently, we have demonstrated that angiopoietin 2 (Ang2) induces pericyte apoptosis via integrin signaling in DR.16 Hyperglycemia-induced Ang2 has a central role in pericyte apoptosis by Ang2/α3β1-integrin/p53 signaling pathway in streptozotocin (STZ)-induced diabetic mice. This evidence concerns the gene ANGPT2 and diabetes mellitus.