KCNB1 and early-onset autosomal dominant Alzheimer disease: With this conceptual framework as reference, we studied the potential relationship occurring between changes in the levels of oxidative stress, alterations of Kv2.1-dependent K+ currents, and variations in neuronal intrinsic activity in hippocampal neurons obtained from 3xTg-AD (triple transgenic mouse model of Alzheimer's disease) mice.