KCNB1 and Alzheimer disease: Kv2.1-dependent current density values were instead found to be significantly lower in 3xTg-AD neurons (average current density values (pA/pF) recorded from 17 neurons were 24.066±2.061 (S.E.M.)at +30 mV, 28.632±2.48 (S.E.M.)at +40 mV, 32.258±2.774 at +50 mV and 35.770±3.064 (S.E.M.)+60 mV; Figure 2a and b) compared with Non-Tg cells (average pA/pF values in 10 neurons were 33.147±4.171 (S.E.M.)at +30 mV (P<0.05), 39.331±5.008 (S.E.M.)at +40 mV (P<0.01), 46.503±5.961 at +50 mV (P<0.001) and 51.151±6.448 at +60 mV (P<0.001); Figure 2a and b).