KCNB1 and Alzheimer disease: Oxidized Kv2.1 channels assemble in oligomers that are held together by disulfide bridges involving Cys-73.12 The oligomerization process has been shown to lead to progressive accumulation of dysfunctional aggregates on neuronal plasma membranes.11, 12 To evaluate whether chronic oxidative stress induces Kv2.1 channel oligomerization in our AD model, hippocampal neurons were fixed and stained with a Kv2.1 antibody and clustering analysis performed.