The difference in adipocytes size is highly relevant, since it has been shown that there is an adipocyte size threshold after which the risk of T2DM increases exponentially.10 Consistent with the increased number of smaller cells in caspase-2 knockout mice, these cells also had increased expression of cyclins, suggesting increased proliferative activity in the adipose cells of caspase-2-deficient mice (Figure 3d). This evidence concerns the gene CASP2 and type 2 diabetes mellitus.