Previously we showed that caspase-2 expression is markedly upregulated in human nonalcoholic steatohepatitis (NASH), correlating with fibrosis severity in patients.20 In the mouse MCD diet model of steatohepatitis, caspase-2 was not only upregulated, but had a crucial role in liver injury and fibrogenesis.20 Here we report that there is also a tremendous upregulation of caspase-2 expression in the Western diet mouse model of NASH (Supplementary Figure 5). The gene discussed is CASP2; the disease is metabolic dysfunction-associated steatohepatitis.