In the ER and Golgi, UBIAD1 may interact with HMGCR and SOAT1, and thus affect cholesterol synthesis and storage [35].A previous report showed that wild-type UBIAD1 was transported via the endomembrane system from the ER to the Golgi in bladder carcinoma cells, while mutant proteins could not be transported [22]. This evidence concerns the gene HMGCR and urinary bladder carcinoma.