TAT and Hypoglycemia: Our data for the Cyp2c23 promoter, suggesting that glucocorticoids associate with alterations in DNA methylation that may facilitate gene transcription are in agreement with previous studies showing that glucocorticoids induce demethylation of the hepatic tyrosine aminotransferase gene promoter in late gestation, which is permissive for transcription factor binding 17 and the induction of transcription in early postnatal life in response to hypoglycemia.18