IRS1 and breast carcinoma: In addition, miR-148a is associated with osteogenic differentiation [37] and angiogenesis in breast cancer by targeting not only v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (ERBB3) [38] but also DNA methyltransferase-1 (DNMT1), insulin-like growth factor-1 receptor (IGF-1R), and insulin receptor substrate-1 (IRS-1) [39].