MTHFR and neural tube defect: Two SNPs in MTHFR, 677C>T, and 1298A>C, were evaluated in our cases as (1) reduced MTHFR function has been reported for carriers of 677TT (~30 % function of controls) and 1298CC (~57 % function of controls) [10, 11]; and (2) an association between the 677TT genotype and NTD status has been consistently reported (odds ratio of 1.8 for NTD infant carriers) [9].