Because BACE-1 is a critical enzyme in the amyloid precursor protein (APP) amyloidgenic pathway that generates β-amyloid, the main component of amyloid plaque in the brain of AD [23], the BACE-1 inhibitory activity of all EEP samples was elucidated using a fluorescence resonance energy transfer enzyme assay (Table 4). The gene discussed is APP; the disease is Alzheimer disease.