Because BACE-1 is a critical enzyme in the amyloid precursor protein (APP) amyloidgenic pathway that generates β-amyloid, the main component of amyloid plaque in the brain of AD [23], the BACE-1 inhibitory activity of all EEP samples was elucidated using a fluorescence resonance energy transfer enzyme assay (Table 4). Here, BACE1 is linked to Alzheimer disease.