The present study indicates that AH may improve the pancretic β-cell damage and exhibit pancreatic anti-inflammatory activity through a reduction of hyperglycemia and/or inhibition of NF-кB-related pro-inflammatory cytokine expressions via the up-regulation of HO-1 protein expression in pancreas of STZ-induced type 1 diabetic rats. The gene discussed is HMOX1; the disease is Hyperglycemia.