Horiguchi et al. found that only 37.5% and 68.8% of the chordomas showed positive staining for β-catenin and E-cadherin respectively15 and Cho et al. reported that only 7.1% and 14.2% of the chordomas showed positive staining for β-catenin and E-cadherin respectively4. This evidence concerns the gene CDH1 and chordoma.