TIAM1 and metastatic melanoma: This was particularly evident in the mesenchymal NIH3T3 cells in which we show that expression of Tiam1 induces an epithelial-like morphology accompanied by reduced cell migration, as previously described by Sander et al.29 A similar phenotypic switch is also seen in metastatic melanoma cells, in which Tiam1 is shown to impede cell migration through regulating the actin cytoskeleton to promote cell–cell contacts and induce an epithelial-like morphology30.