CRP and metabolic syndrome: Also in metabolic syndrome subjects, red orange juice containing 160 mg hesperidin for 1 week improved FMD, blood CRP, IL‐6 and α‐TNF, but not plasma NO concentration 27, while in moderately overweight men, hesperidin decreased diastolic blood pressure and improved microvascular endothelial reactivity post‐prandially at the peak of hesperetin plasma concentration 28, and these changes were associated with a more anti‐inflammatory blood leukocyte gene expression profile 29.