The total point was raised by adding the score of tumor depth (0 for T1 + T2, 94 for T3 + T4), lymph node metastasis (0 for N0 + N1, 51 for N2, 100 for N3), and IDO expression (0 for low, and 52 for high) for each patients correspondingly (Fig. 4b). This evidence concerns the gene IDO1 and metastatic malignant neoplasm in the lymph nodes.