IDO1 and neoplasm: The total point was raised by adding the score of tumor depth (0 for T1 + T2, 94 for T3 + T4), lymph node metastasis (0 for N0 + N1, 51 for N2, 100 for N3), and IDO expression (0 for low, and 52 for high) for each patients correspondingly (Fig. 4b).