Our data indicate that expression of S1P receptors S1P1, S1P2 and S1P3 as well as of SphK1 is up-regulated in GBM tissue in comparison to non-malignant brain whereas SphK2 was unchanged and a trend to a lower expression of S1P5 was observed in GBM. This evidence concerns the gene S1PR1 and glioblastoma.