HSPA5 and neoplasm: The “big-picture” conclusions we had previously made concerning the biology of the drug prior to the present manuscript were that OSU-03012 (AR-12) kills tumor cells selectively over non-transformed cells and does so by primarily inactivating and down-regulating the chaperone GRP78 which causes a prolonged intense endoplasmic reticulum stress response leading to high levels of autophagy flux, mitochondrial dysfunction and an apparent necroptotic form of tumor cell death.