In transformed rodent fibroblasts, AR-12 increased the expression of Beclin1 and LC3 in a PERK dependent manner, in general agreement with the present data in human tumor cells showing that dominant negative eIF2 alpha also suppressed AR-12–induced expression of the autophagy regulatory, and autophagy facilitating proteins, Beclin1 and LC3. This evidence concerns the gene BECN1 and neoplasm.