LP117 also sensitized a range of further ABCB1-expressing cell lines to vincristine, including two other neuroblastoma cell lines with acquired resistance to vincristine (IMR-32rVCR10, UKF-NB-2rVCR10), UKF-NB-3 sub-lines adapted to doxorubicin (UKF-NB-3rDOX20) or paclitaxel (UKF-NB-3rPCL10), and the intrinsically ABCB1-expressing neuroblastoma cell line UKF-NB-4 [20,22,24] but did not sensitize UKF-NB-3rDOX20 or UKF-NB-3rVCR10 cells to the non-ABCB1 substrate cisplatin. This evidence concerns the gene ABCB1 and neuroblastoma.