In 65 cases (mature B-ALL, n = 8 (12%); c-ALL, n = 27 (42%); precursor B-ALL, n = 23 (35%); T-ALL, n = 7 (11%)), data on HER2/neu expression on ALL blasts were available, comprising 17 patients (26%) with HER2/neu surface expression and 48 patients (74%) without. This evidence concerns the gene ERBB2 and acute lymphoblastic leukemia.