It has been previously demonstrated that Nutlin-3a induces apoptosis in pediatric ALL with wild-type TP53 and over-expression of MDM2 [22], and that inhibition of PI3K/AKT pathway synergized the ability of Nutlin-3a to induce apoptosis in a set of ALL cell lines [23]. This evidence concerns the gene MDM2 and acute lymphoblastic leukemia.