Microscopic invasion of tumor into the perithyroidal soft tissuesRAI avid metastatic foci in the neck on the first post-treatment whole-body RAI scanAggressive histology (e.g. tall cell, hobnail variant, columnar cell carcinoma)Papillary thyroid cancer with vascular invasionClinical N1 or >5 pathologic N1 with all involved lymph nodes <3 cm in largest dimension*Multifocal papillary microcarcinoma with extrathyroidal extension and V600E BRAF mutated (if known)*. This evidence concerns the gene BRAF and neoplasm.