These results suggest that TSH suppression therapy decreases the rate of recurrences and mortality only in patients with high-risk differentiated thyroid cancer.12 Although the reduction in serum levels of thyroglobulin associated with low TSH levels provide indirect evidence of the efficacy of TSH suppression, increasing the degree of suppression to produce serum TSH levels below 0.5 mU/L does not result in further decrease in thyroglobulin levels. The gene discussed is TG; the disease is thyroid gland carcinoma.