This syndrome is caused by loss of genes imprinted on 15q11-q13 region such as gamma-aminobutyric acid (GABA) A receptor, gamma 3 (GABRG3), imprinted in Prader-Willi syndrome (IPW), small nucleolar RNA, C/D box 116 cluster (PWCR1), small nuclear ribonucleoprotein polypeptide N (SNRPN) and MAGE-like 2 (MAGEL2). The gene discussed is SNRPN; the disease is Prader-Willi syndrome.