IGHG3 and parasitic infectious disease: Nevertheless, in this study, we could not confirm whether the increase in levels of IgG2 and IgG3 antibodies against PvRAMA was completely associated with the degree of protective immunity to P. vivax. Further studies are required to determine the correlation of anti-PvRAMA IgG2 and IgG3 antibody levels with a reduction in parasitemia and the rate of reinfection with P. vivax.